This is a tough one. As I said the best immediate option is the transplantation of age appropriate T cell progenitors … like the one I found. But these important sciences keep getting defunded and most science has been rerouted to AI and not any founding science.
Sadly these are not things AI can do.
One important aspect for now.
Our gut has an immune system and we found that T cells can be made there as well. Also other extra thymic sites are liver and spleen. But the most promising is the gut. Keeping the gut healthy with good microbiome, diet and exercise can help a lot to boost the T cells.
The T cells I found in the gut (in mice) was CD8+ T cells. These are the cells relevant for infection and fighting cancer cells.
I will deep dive over the next couple of weeks on this angle to see what more can be done 👍
This really explains something you see all the time. Some people stay mentally razor sharp but their bodies slow down, while others remain physically active but start struggling cognitively. Good article!
But it looks like the cognitively sharp survive better.
Of course, staying cognitively sharp requires better lifestyle choices, such as sleep, diet, exercise, etc., and this can trickle down to all other organs and their health, too.
I think many things are interconnected. Sometimes we can make good choices to change all these outcomes.
Of course, someone could be making better lifestyle choices, but could be living with a person who smokes and experiences secondhand smoke and related lung issues.
Thanks very much Harshi for bringing out all the Nature Medicine research on organ aging. All said and done - life style plays a huge role in aging. I have seen my grand parents aging naturally - simple veg-food, joint family system (managing stress), walk to all destinations (no vehicles and no pollution), Ayurveda for any minor problems and so on. Thanks again for a beautiful article
The amount of things that we are still learning about our bodies is marvelous! It's interesting to think my organs could be 10 years older than each other. 😅
Frustrated about steady decline in Thymus... the "finishing school" for immune system cells. There is some work under way but not widely recognized.
This is a tough one. As I said the best immediate option is the transplantation of age appropriate T cell progenitors … like the one I found. But these important sciences keep getting defunded and most science has been rerouted to AI and not any founding science.
Sadly these are not things AI can do.
One important aspect for now.
Our gut has an immune system and we found that T cells can be made there as well. Also other extra thymic sites are liver and spleen. But the most promising is the gut. Keeping the gut healthy with good microbiome, diet and exercise can help a lot to boost the T cells.
The T cells I found in the gut (in mice) was CD8+ T cells. These are the cells relevant for infection and fighting cancer cells.
I will deep dive over the next couple of weeks on this angle to see what more can be done 👍
This really explains something you see all the time. Some people stay mentally razor sharp but their bodies slow down, while others remain physically active but start struggling cognitively. Good article!
Right!!
But it looks like the cognitively sharp survive better.
Of course, staying cognitively sharp requires better lifestyle choices, such as sleep, diet, exercise, etc., and this can trickle down to all other organs and their health, too.
I think many things are interconnected. Sometimes we can make good choices to change all these outcomes.
Of course, someone could be making better lifestyle choices, but could be living with a person who smokes and experiences secondhand smoke and related lung issues.
Thanks very much Harshi for bringing out all the Nature Medicine research on organ aging. All said and done - life style plays a huge role in aging. I have seen my grand parents aging naturally - simple veg-food, joint family system (managing stress), walk to all destinations (no vehicles and no pollution), Ayurveda for any minor problems and so on. Thanks again for a beautiful article
You are very welcome!
And yes!! Lifestyle choices matter. All organs are interconnected and what we do right now can change everything.
I wish you and your family all the health with your great choices.
The amount of things that we are still learning about our bodies is marvelous! It's interesting to think my organs could be 10 years older than each other. 😅
Haha yes.
But once we make the correct lifestyle choices we change many things. We can make all of these organs 10 years younger than our biological age :))